Effects of electroporation on cytotoxicity of 4-aminopyrimidin-2-(1H)-one based ligand and its Cobalt (II) and Ruthenium (II) complexes in MCF-7 cancer cells
نویسندگان
چکیده
Objective: The aim of this study was to investigate the underlying causes obstetrical disseminated intravascular coagulation (DIC) Cancer is a complicated disease and ranks near top among death across world. Electrochemotherapy (ECT) local treatment method in which chemotherapy electroporation (EP) are used combination facilitate entry drugs into cells. purpose examine cytotoxicity cytosine-based ligand its cobalt ruthenium complexes MCF-7 cancer cells L-929 healthy cells, determine effects EP on anticancer activities these compounds.
 Methods: In present study, firstly, cytotoxic (Co) (Ru) were examined against Then, compounds Cytotoxicity determined by MTT viability test. 
 Results: Co(II) Ru(II) showed best while they displayed low increased significantly (p
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ژورنال
عنوان ژورنال: Dicle Medical Journal
سال: 2021
ISSN: ['1300-2945', '1308-9889']
DOI: https://doi.org/10.5798/dicletip.988061